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By: Rebecca S. Pettit, PharmD, MBA, BCPS, BCPPS

  • Pediatric Pulmonary Clinical Pharmacy Specialist, Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana

It becomes increasingly more frequent above the age of 50 years and its incidence approaches 75-80% in men above 80 years hypertension jnc 7 guidelines discount tenormin 100 mg on-line. With advancing age heart attack jack smack u blue buy tenormin american express, there is decline in the level of androgen and a corresponding rise of oestrogen in the males heart attack nitroglycerin buy generic tenormin on-line. G/A the enlarged pro state is nodular blood pressure chart guide discount tenormin master card, smooth and frm and weighs 2-4 times its normal weight i. The appearance on cut section varies depending upon whether the hyperplasia is predominantly of the glandu lar or fbromuscular tissue. M/E There is hyperplasia of all three tissue elements in varying proportions—glandular, fbrous and muscular: Glandular hyperplasia predominates in most cases and is identifed by exaggerated intra-acinar papil lary infoldings with delicate fbrovascular cores. The presenting features include frequency, nocturia, diff culty in micturition, pain, haematuria and sometimes, the patients present with acute retention of urine requiring immediate catheterisation. It is a disease of men above the age of 478 50 years and its prevalence increases with increasing age. Latent carcinoma this is found unexpectedly as a small focus of carcinoma in the prostate during autopsy studies in men dying of other causes. Occult carcinoma this is the type in which the patient has no symptoms of prostatic carcinoma but shows evidence of metastases on clinical examination and investigations. Clinical carcinoma Clinical prostatic carcinoma is the type detected by rectal examination and other investi gations and confrmed by pathologic examination of biopsy of the prostate. Endocrinologic factors Androgens are considered essential for development and maintenance of prostatic epithelium. Racial and geographic infuences There are some racial and geographic differences in the incidence of prostatic cancer. Environmental infuences these include high dietary fat, and exposure to polycyclic aromatic hydrocarbons. Nodular hyperplasia Approximately 15-20% of nodular hyperplastic prostates harbour carcinoma. In 95% of cases, prostatic carcinoma is located in the peripheral zone, especially in the posterior lobe. M/E 4 histologic types are described—adenocarcinoma, transitional cell carcinoma, squamous cell carcinoma and undifferentiated carcinoma. The histologic characteristics of adenocarcinoma of the prostate are as under: 1 Architectural disturbance In contrast to convoluted appearance of the glands seen in normal and hyperplastic prostate, there is loss of intra acinar papillary convolutions. The groups of acini are either closely packed in back-to-back arrangement without intervening stroma or are haphazardly distributed. Stroma Normally, fbromuscular sling surrounds the acini, whereas malignant acini have little or no stroma between them. Gland pattern Most frequently, the glands in well-differentiated prostatic adenocarcinoma are small or medium-sized, lined by a single layer of cuboidal or low columnar cells. Moderately-differentiated tumours have cribriform or fenestrated glandular appearance. Tumour cells the outer basal layer seen in the normal or benign acini 479 is lost. The cells may show varying degree of anaplasia and nuclear atypia but is generally slight. Invasion One of the important diagnostic features of malignancy in prostate is the early and frequent occurrence of invasion of intra-prostatic perineural spaces. Direct spread Direct extension of the tumour occurs into the prostatic capsule and beyond. In late stage, the tumour may extend into the bladder neck, seminal vesicles, trigone and ureteral openings. Haematogenous spread leads most often to characteristic osteoblastic osseous metastases, especially to pelvis, and lumbar spine; other sites of metastases are lungs, kidneys, breast and brain. Two biochemical serum tumour markers employed for diagnosis and monitoring the prognosis of prostatic carcinoma are as under: 1. A reading between 4 and 10 ng/ml (normal 0-4 ng/ml) is highly suspicious (10% risk) but value above 10 is diagnostic of prostatic carci noma. Treatment of prostatic carcinoma consists of surgery, radiotherapy and hormonal therapy. The hormonal dependence of prostate cancer consists of depriving the tumour cells of growth-promoting infuence of testosterone. This can be achieved by bilateral orchiectomy followed by administration of oestrogen. In an undescended testis the risk of developing a testicular malignancy is increased to average of: A. Granulomatous orchitis is the term used for infam mation of testis due to following etiology: A. Spermatocytic seminoma differs from classic seminoma in the following respects except: A. The inner surface of labia majora, labia minora and vestibule are covered by stratifed squamous epithelium. Bartholin’s or vulvovaginal glands are located one on each side of the mass of tissue forming labia majora. M/E Shows the usual appearance of acute suppurative infammation with neutrophilic infltration, hyperaemia, oedema and epithelial degeneration. Alternatively, the chronic process evolves from repeated attacks of less severe acute infammation which may be short of abscess formation and resolves incompletely. In either case, the chronic infammatory process terminates into fuid-flled Bartholin’s cyst. M/E Shows variable lining of the cyst varying from the transitional epithe lium of the normal duct to a fattened lining because of increased intracystic pressure. The cyst wall may show chronic infammatory infltrate and a few mucus-secreting acini. The term is applied to chronic lesions of the vulva characterised clinically by white, plaque-like, pruritic mucosal thickenings and pathologically by disorders of epithelial growth. Clinically, the patient, usually a post-menopausal woman, complains of intense pruritus which may produce excoriation of the affected skin. Eventually, there is progressive shrinkage and atrophy resulting in narrowing of the introitus, clinically referred to as kraurosis vulvae. Lichen sclerosus is not a premalignant lesion and responds favourably to topical treatment with androgens. The stroma consists of loose fbrous and myxomatous connective tissue with some adipose tissue and blood vessels. Most commonly, it is located in the labia or in the perianal region as a small sharply circumscribed nodule. The tumour consists of papillary structures composed of fbrovascular stalk and is covered by double layer of epithelial cells—a layer of fattened myoepithelial cells and an overlying layer of columnar cells. The affected skin, most often on the labia majora, appears as map-like, red, scaly, elevated and indurated area. Unlike Paget’s disease of the breast in which case there is always an underlying ductal carcinoma, extra-mammary Paget’s disease is confned to the epidermis in most cases. Vulvar cancer is squamous cell type with varying degree of anaplasia and depth of invasion depending upon the stage. Verrucous carcinoma is a rare variant which is a fungating tumour but is locally malignant. M/E the vaginal wall consists of 3 layers: an outer fbrous, a middle muscular and an inner epithelial. The epithelial layer consists of stratifed squamous epithelium which undergoes cytologic changes under hormonal stimuli. Oestrogen increases its thickness such as during reproductive years, whereas the epithelium is thin in childhood, and atrophic after menopause when oestrogen stimulation is minimal. Certain other infections are quite common in the vulva and vagina as follows: i) Bacterial. The most common causes of vaginitis are Candida (moniliasis) and Trichomonas (trichomoniasis). Squamous cell dysplasia or vaginal intraepithelial neoplasia occur less frequently as compared to the cervix or vulva and can be detected by Pap smears. Squamous cell carcinoma of vagina constitutes less than 2% of all gynaecologic malignancies and is similar in morphology as elsewhere in the female genital tract. Adenocarcinoma of the vagina is much less frequent than squamous cell carcinoma of the vagina.


  • Orbital cellulitis or periorbital cellulitis
  • Using stool softeners
  • Drink warm liquids such as lemon tea or tea with honey.
  • Food through the digestive system.
  • Treating nausea caused by chemotherapy in cancer patients
  • Birth defects with the bladder or urethra
  • Blood in your stools or your stools appear black or tarry
  • Have frequent periods or they last 7 or more days
  • Diabetes
  • Fever

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M/E the most characteristic feature is the proliferation of basaloid cells (resembling basal layer of epidermis) blood pressure 80 60 order tenormin 50 mg overnight delivery. A variety of patterns of these cells may be seen: solid masses artery dorsalis pedis buy discount tenormin online, masses of pigmented cells prehypertension vegetarian tenormin 100 mg for sale, strands and nests of tumour cells in morphea pattern kamaliya arrhythmia buy tenormin 100 mg without a prescription, keratotic masses, cystic change with sebaceous differentiation, and adenoid pattern with apocrine or eccrine differentiation. The most characteristic histologic feature is the presence of multiple horn cysts having keratinised centre and surrounded by basophilic cells resembling basal cells. These horn cysts simulate abortive pilar structures which are interconnected by epithelial tracts. The masses of tumour cells embedded in cellular stroma characteristically 530 consist of 2 types of cells: the peripheral basophilic cells resembling hair matrix cells, and the inner shadow cells having central unstained shadow in place of the lost nucleus. Initially, the lesion appears as a hairless plaque, but later it becomes verrucous and nodular. M/E Naevus sebaceus is characterised by hyperplasia of immature sebaceous glands and pilar structures. The tumour is composed of irregular lobules of incompletely differentiated sebaceous glands. M/E the tumour is composed of variable-sized lobules of poorly differentiated cells containing some sebaceous cells. The tumour cells show marked cytologic atypia such as pleomorphism and hyperchromasia. M/E It consists of tumour cells arising from the lower portion of the epidermis and extending downward into dermis as broad anastomosing bands. M/E Hidradenoma consists of solid masses and cords of tumour cells which may have an occasional duct-like structure containing mucin. The tumour lobules contain 2 types of epithelial cells like in the secretory coils of the eccrine sweat gland. Peripheral cells are small with dark nuclei, while the centre of lobules contains large cells with pale nuclei. Papillary hidradenoma represents an adenoma with apocrine differentiation and containing papillary, tubular and cystic structures. M/E the tumour is composed of irregular islands of tumour cells creating 531 a pattern resembling jigsaw puzzle. The tumour cells comprising the islands consist of 2 types of epithelial cells: peripheral small cells with dark nuclei, and inner large cells with light staining nuclei. They are often fat or slightly elevated lesions; rarely they may be papillomatous or pedunculated. M/E Irrespective of the histologic types, all naevocellular naevi are composed of ‘naevus cells’ which are actually identical to melanocytes but differ from melanocytes in being arranged in clusters or nests. Naevus cells are cuboidal or oval in shape with homogeneous cytoplasm and contain large round or oval nucleus. Melanin pigment is abundant in the naevus cells present in the lower epidermis and upper dermis, but the cells in the mid dermis and lower dermis hardly contain any melanin. The important histological variants of naevi are as under: i) Lentigo is the replacement of the basal layer of the epidermis by melanocytes. These lesions, in addition to the junctional activity as in junctional naevi, show nests of naevus cells in the dermis to a variable depth. The lesion is mainly located in the upper dermis as nests and cords of naevus cells. The naevus cells are, however, elongated and epithelioid in appearance which may or may not contain melanin. These lesions are larger than the usual acquired naevi, are often multiple, and appear as fat macules to slightly elevated plaques with irregular borders and variable pigmentation. The etiology is unknown but there is role of excessive exposure of white skin to sunlight. Besides the skin, melanomas may occur at various other sites such as oral and anogenital mucosa, oesophagus, conjunctiva, orbit and leptomeninges. Some high risk factors associated with increased incidence of malignant melanoma are as under: i) Persistent change in appearance of a mole. G/A Depending upon the clinical course and prognosis, cutaneous malignant melanomas are of the following 5 types: i) Lentigo maligna melanoma this often develops from a pre-existing lentigo. M/E Irrespective of the type, following features are seen: i) Origin the malignant melanoma, whether arising from a pre-existing naevus or starting de novo, has marked junctional activity at the epidermo dermal junction and grows downward into the dermis. The tumour cells have amphophilic cytoplasm and large, pleomorphic nuclei with conspicuous nucleoli. These tumour cells may be arranged in various patterns such as solid masses, sheets, island, alveoli etc. The prognosis for patients with malignant melanoma depends upon the stage at presentation. Metastatic spread of malignant melanoma is very common and takes place via lymphatics to the regional lymph nodes and through blood to distant sites like lungs, liver, brain, spinal cord, and adrenals. Just as in breast cancer, sentinel lymph node biopsy is quite helpful in evaluation of regional nodal 533 status. The commonest sites are the lower and upper extremities, followed in decreasing frequency, by abdominal cavity and retroperitoneum. The benign variant is also known by various synonyms like dermatofbroma, histiocytoma, sclerosing haemangioma, fbroxanthoma and xanthogranuloma. Benign histiocytomas are often small but malignant fbrous histiocytomas may be of enormous size. M/E the tumours are composed of spindle­shaped fbrohistiocytoid cells which are characteristically arranged in cartwheel or storiform pattern. The benign variety contains uniform spindle-shaped cells with admixture of numerous foamy histiocytes. The malignant fbrous histiocytoma shows pleomorphic tumour cells and some multinucleate giant cells in a stroma that may show myxoid change and infammatory infltrate. The tumour usually forms a solid nodule, within the dermis and subcutaneous fat, protru ding the epidermis outwards. M/E the tumour is very cellular and is composed of uniform fbroblasts arranged in a cartwheel or storiform pattern. M/E Xanthomas are composed of dermal collections of benign-appearing foamy histiocytes. Multinucleate tumour giant cells surrounded by lipid-laden cytoplasm are often present. The examples are Langerhans’ cell histiocytosis, mycosis fungoides, mastocytosis, lymphomas and leukaemias. In about half the cases, there is formation of intraepidermal clusters of atypical lymphoid cells forming Darier-Pautrier’s microabscesses. Which of the following is true about the behaviour of dermato fbrosarcoma protuberans Neuroendocrine cells which are present in the gastric and intestinal mucosa and elaborate peptide hormones. Neuroganglia cells lie in the ganglia cells in the sympathetic chain and elaborate amines. Islets of Langerhans in the pancreas (included in both endocrine and neuroendocrine systems) secrete insulin. Isolated cells in the left atrium of the heart secrete atrial natriuretic (salt losing) peptide hormone. Broadly speaking, human hormones are divided into 5 major classes which are further grouped under two headings depending upon their site of interactions on the target cell receptors (whether cell membrane or nuclear receptor): Group I: Those interacting with cell-surface membrane receptors: 1. Major functions of hormones are as under: i) Growth and differentiation of cells: by pituitary hormones, thyroid, parathyroid, steroid hormones. A basic feature of all endocrine glands is the existence of both negative and positive feedback control system that stimulates or regulates hormone production in a way that levels remain within the normal range. In general, pathologic processes affecting endocrine glands with resultant hormonal abnormalities may occur from following processes: Hyperfunction this results from excess of hormone secreting tissues. Hypofunction Defciency of hormones occurs from destruction of hormone-forming tissues from infammation (often autoimmune), infections, iatrogenic. Hormone resistance There may be adequate or excessive production of a hormone but there is peripheral resistance, often from inherited mutations in receptors.

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I participated in a number of centrifuge programs over the years at Langley and Johnsville blood pressure medication overdose treatment buy genuine tenormin online. I never worried about where the “nightlife” was after dinner in Johnsville or Philadelphia arteria axilar order tenormin 50mg on-line, as I was more than ready to arrhythmia center of connecticut discount tenormin 50mg overnight delivery get some rest in order to pulse pressure between aorta and capillaries cheap tenormin 100mg on-line be ready for the next day “on the wheel. During the centrifuge programs, service pilots were occasionally invited to participate. Even though I only knew him for a couple of days at the centrifuge, I could not help but be impressed. I wasn’t surprised, some months later, when he was selected as one of the original seven astronauts. Things were hectic at Langley as people sought to find where they fit into the new organization. There were some pretty wild proposals going around, initially, as the engineers and scientists worked to put a program together to get a man into space. There were also some pretty unusual simulation projects started and, fortunately, not all were completed. The one that I recall best (because I was assigned to it) was a real “spook” of a program. The plan involved evaluation of a pilot under conditions of simulated “zero g”. A large spherical steel tank was welded together and assembled at the rear of one of the engineering buildings. The plan called for a pilot’s seat in the center of the tank and an air supply for the test subject through an oxygen mask and hose. A communications link would connect the occupant to an outside monitoring station. The purpose of the test was to see if the subject pilot could determine his orientation under zero-g (simulated by floating in water) as his seat was moved to different positions in the center of the tank. The test pilots in our office were called in, almost as an afterthought, when it was decided that we would be good subjects to conduct zero-g research. I had serious concerns regarding the safety of this large steel ball full of water. How was a test subject to get out if there was a problem with the breathing or communications system The whole design philosophy of the tank seemed poor, as far as safety was concerned. This was probably a result of the immediate hysteria that was running through the agency with regards to the new “space race. According to the plan, the consultant engineer with diving experience was going to be the initial test subject for the tank. As it turned out, on the first or second trial in the ball, something failed in the breathing system and the diver almost drowned. First, I was glad the diver survived, but almost as important, I was glad that this particular program was scrapped. I never had a second thought about continuing as a test pilot after the helicopter crash, but I was considering thoughts of giving it up when faced with assignments like the water tank. After reading the handbook and studying the aircraft systems, I scheduled several simulator flights for practice prior to flying the actual aircraft. I’ll never forget that after my first ride in the simulator, I told the Air Force sergeant operating it that it must need some adjustment. The control response was sensitive and it was difficult not to oscillate the aircraft around the pitch axis during the final approach. The sergeant seemed a little let down and said that none of his Air Force pilots had complained, but he would check out all of the parameters to make sure that nothing had slipped or changed in the simulator’s programming. The longitudinal control felt exactly the same in the aircraft as in the simulator. The additional visual and physical cues that were available in actual flight helped a great deal. I made a point of telling the simulator operator the very next day that his simulator was fine. Characteristics such as this are more difficult to fly on fixed-base simulators where there are no motion cues and limited visual cues. This gives him more information to work with and helps prevent the over-controlling. When a pilot evaluates an aircraft that has difficult flying qualities, the problem areas are usually apparent even if it takes a little time to sort out in detail exactly what is causing the problem. After the same pilot experiences these problems repeatedly or continuously, his mental “computer”. His mind (the “computer”) and his servo actuators (his nerves, muscle, and body structure) have definite limits as to what they can handle. Actually, the aircraft’s static stability was marginal and its maneuvering stability was negative a great deal of the time. This means that while pulling acceleration or g’s in high-speed turns, the pilots would have to push on the stick rather than pull normally. Considering all of this, the P-47 pilot liked his aircraft and was able to perform admirably with it. Does this mean that aircraft designers and builders need not consider the handling qualities or flying capabilities of their aircraft Mallick used it to establish a minimal (yet satisfactory) handling qualities envelope for the Navy’s operational Panther jets. If the pilot’s capabilities are largely occupied with keeping the aircraft flying, he will likely become saturated during demanding maneuvers or emergency situations. Another area where poor handling qualities become apparent in an aircraft is during the familiarization stages of flying. If he encounters an especially difficult condition in flight, the combination the aircraft’s flying qualities and the pilot’s experience can wind up as an incident, accident, or at least a good scare. Other Interesting Jet Programs at Langley At Langley, we had a Grumman F9F-2 Panther jet with a very unusual flight control system. A side-arm controller could be adjusted for force input, displacement input, or a combination of the two. In addition, the control system of the aircraft could be set up for rate response or acceleration response. He found it had excellent handling qualities, but only marginal engine perfor mance for operational use. To this end, we experimented with air-to-air tracking of a target aircraft, usually the F2H-1 discussed earlier. The pilot’s measured tracking performance, along with his qualitative evaluation, provided the desired information. The Panther’s fuel transfer system was modified and the pilot had the capability of transferring fuel aft following takeoff to cause the aircraft to become statically and dynamically unstable to the point that it would lose control if not held steady by the pilot. This presented the pilot with a difficult task in tracking a target aircraft while flying an unstable aircraft. The purpose of the center of gravity control was to enlarge the range of the evaluation envelope. The pilot transferred fuel forward prior to landing, to return the aircraft to a safe flying condition, and then land using the conventional flight control system. Technicians also mounted a small steel container far back on the lower fuselage and loaded it with 250 pounds of Number 7 lead shot. This shifted the center of gravity aft near the unstable condition but within a safe margin for takeoff and landing. In an emergency the pilot could activate two explosive bolts to jettison the contents of the box, allowing an immediate forward shift of the aircraft’s center of gravity. The small size lead shot was selected to reduce the threat to anybody on the ground, in the remote chance that it fell on them after jettison. We often flew with very poor handling qualities while still attaining satisfactory target tracking. One false move, or relaxation of concentration, could result in a pitch-up or loss of control. The program to establish the minimums for a satisfactory handling quality envelope was interesting.

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Surgeons attempt to arteria jugularis purchase tenormin 50mg free shipping put intervening tissue or graft(Surgisys) between the tracheal repair and the esophageal anastomosis to arrhythmia in children tenormin 50mg without a prescription prevent this complication blood pressure medication harmful order tenormin with mastercard. Tracheomalacia is one of the differential diagnoses in children with apenea and bradycardia episodes after definitive surgery arrhythmia 16 year old cheap tenormin american express. A rigid bronchoscopy in a spontaneously breathing child is required to make the diagnosis of tracheomalacia; the posterior trachea coapts with the anterior trachea during expiration. If tracheomalacia is severe, an aortopexy (aorta is pexed to the underside of the sternum) may be necessary. It is hypothesized that the distal esophageal dissection added to the cephalad pull on the distal esophagus straightens out the gastroesophageal junction, leading to increased reflux in this population. If reflux leads to recurrent aspiration pneumonias, significant apnea, emesis leading to failure to thrive, repeated episodes of anastomotic stricture, a fundoplictaion may be necessary. It is thought that this may be due to the natural disappearance of the right umbilical vein during the course of fetal development. Associated anomalies are rare except for intestinal atresia (10-15%) of cases Risk factors include maternal use of tobacco, salicylates, pseudoephedrine, or phenylpropanolamines during the first trimester. Management in the Delivery Room In the delivery room, an airway if infant in respiratory distress. The intestines should be handled gently making sure that the mesentery is straight. The bowel is placed on top of abdomen without tension to avoid impediment to venous drainage and to avoid inducing bowel edema and injury. The baby should be have his legs placed in a plastic bag (bowel bag) or if this is not 391 available, the bowel should be carefully wrapped in warm saline-soaked gauze. The baby’s position should be optimize position of baby (see above) Operative Decision Making In some institutions, the decision whether a primary fascial closure versus a silo closure is performed is determined the in the operating room. The decision whether the abdominal wall is closed or a silo is placed depends upon the physiologic ramifications of having the intestines inside. Post-operative Management: Primary Abdominal Closure: the baby is extubated as soon as possible. The baby requires sedation and pain medication about 15 minutes before the reduction. The baby’s ventilator settings may need to be temporarily increased during the reduction due to the sedation and increased abdominal pressure. Apply gentle pressure on the intestines, pushing the intestines about 2-3 cm during each reduction. Keep the silo vertical by securing the bag with another umbilical tape to the top of the bed. If a “giant” omphalocoele (>5 cm), C-section is warranted Incidence of omphalocele is ~ 1 in 6, 000-10, 000 live births Like gastroschisis, omphaloceles are now most commonly diagnosed prenatally. Unlike gastroschisis, the defect is contained within umbilical cord, unless ruptured. If the sac is not ruptured, carefully wrap herniated viscera in warm saline-soaked Kerlix. If a ruptured omphalocele is present, the initial management is similar to gastroschisis. Place the baby feet first into a “bowel bag” and tie the bag loosely around the axilla. A sepsis work-up should be considered, especially in ruptured omphalocele patients. Administration of intravenous antibiotics such as ampicillin and gentamycin should be considered. This should include a cardiac echocardiogram, renal ultrasound, and chromosomal studies. Operative Considerations If the defect is small (3cm or less), primary closure can be achieved easily. The baby with giant omphalocoele is often able to breathe without support and eat without any problems. If an omphalocele is closed in the early newborn period, specific attention should be paid when the globular liver is placed in the abdomen. The hepatic veins are longer than normal in these patients and replacement of the liver in the abdomen can kink these veins causing hemodynamic compromise. In addition, replacing all the viscera in the abdomen (with or without a patch) can cause an abdominal compartment syndrome to develop. Atresia is complete obstruction of lumen of the intestine, and stenosis referes to incomplete obstruction of the lumen. The most common intestinal atresia (in decreasing order of frequency) are duodenal, ileal, jejunal. Incidence 1 in 2710 live births (equal sex distribution) Clinical Presentation Infants with intestinal atresias are often diagnosed prenatally. Babies with colonic atresia can present with perforation and/or such significant abdominal distension to require ventilatory support. The differential diagnosis of babies with a bilious vomiting include causes of intestinal obstruction such as malrotation with or without volvulus, intestinal duplication, meconium ileus, Hirschprung disease. Radiological Presentation On prenatal ultrasound, finings may include polyhydramnios or dilated, “echogenic” bowel. Postnatally, duodenal atresias often show a double bubble sign (air in the stomach and in the proximal duodenum). There could be a complete disconnection with blind ending segments of the duodenum. There could be a complete membrane in the duodenal lumen (Type 1) or a perforated membrane (“windsock anomaly”). Other causes of duodenal obstruction in a newborn include annular pancreas, preduodenal portal vein. The presence of an annular pancreas or preduodenal portal vein may not cause an obstruction that is clinically significant. If these congenital anomalies are present, 399 one should look rule out the presence of asplenia/polysplenia or biliary atresia at the time of exploration. Jejunal/ Ileal Atresia the pathogenesis of jejunoileal atresias is thought to be due to vascular insufficiency of an intestinal segment. A suction rectal biopsy should be performed before gastrointestinal continuitiy is re-established in patients with colon atresias. Prophylactic antibiotics should be administered, but should be discontinued within 24 hours. Surgical repair for duodenal atresias usually entail an anastomosis between the bowel proximal and distal to the obstruction. If a web is involved, care is taken not to harm the ampulla, since the ampulla can be involved in the web. For jejunal and ileal atresia, resection of the dilated segment and reanastomosis is performed. If only a limited length of intestine is present, the surgeon would refrain from resecting any intestine. An intestinal lengthening procedure (such as serial transverse enteroplasty) may be done in the future to increase intestinal length. Post-operative management of patients with intestinal atresias typically involves awaiting intestinal function to resume and supporting the patient during this time. Foregut dysmotility takes at least 2-3 weeks’ time to resolve in duodenal atresia. Some centers start early trophic feeds in children with duodenal atresia after a contrast study documents no leakage through a patent anastomosis. In patients with short gut (<40 cm of small intestine), one should monitor for malabsorption and diarrhea (reducing substances in stool). Random urine sodium should be monitored when these patients are on full enteral feeds. Outcome and Potential Complications Most patients with intestinal atresia do well. Predictably, those with a limited length of intestine may have issues relatable to short bowel syndrome. If the dilated segment is not resected, problems with motility in this segment may be seen. This functional intestinal obstruction leads to poor peristalsis, impaired digestion and absorption, as well as bacterial overgrowth.

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